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In 70 percent of cases, physical causes are responsible for erectile dysfunction. Most often, penile blood circulation is disturbed and / or the penile gland itself, which is very similar to the vascular wall musculature, falls ill. Either too little blood in the penis arrives because...
In 70 percent of cases, physical causes are responsible for erectile dysfunction. Most often, penile blood circulation is disturbed and / or the penile gland itself, which is very similar to the vascular wall musculature, falls ill. Either too little blood in the penis arrives because the supplying arteries are "calcified" (arteriosclerosis). Or the blood drains off too quickly through the veins. Or both. In any case, the amount of blood in the erectile tissue of the penis is no longer sufficient for a satisfactory erection.
Various diseases that promote circulatory disorders also increase the risk of erectile dysfunction: Diabetes mellitus (diabetes), hypertension, lipid metabolism disorders. The lifestyle also has a decisive influence: Smoking, obesity, physical inactivity and a one-sided and unhealthy diet increase the blood vessels and thus increase the probability of potency problems. Conversely, a healthy lifestyle helps to prevent potency disorders. It has also been shown repeatedly that a healthy lifestyle and regular exercise exercise a favorable influence on an erectile dysfunction. Erectile dysfunction is often the first warning sign of vascular disease and thus a possible harbinger from heart attack or stroke. If atherosclerosis is detected and treated early, Often bad consequences can be avoided. Not least for this reason, it is advisable to clarify a potency problems medically.
The male sex hormone testosterone seems to have a significantly greater impact on the love life as long suspected. This is shown by recent research results. So is a sufficiently high hormone level apparently a very important condition for a satisfactory erection. With the years of life, testosterone levels in the blood usually fall off in men. A testosterone deficiency (hypogonadism) does not have, but may well lead to impotence. Therefore, if men have erection problems, they should necessarily also have low testosterone levels as a possible cause be considered.
Important to know: Many medications can cause impotence as a side effect, including beta-blockers for high blood pressure, dehydrating medications, lipid-lowering drugs or depression medications. If there is an indication in the instruction leaflet and there is a suspicion that the remedy might be a cause of erectile dysfunction, patients should consult their physician. Maybe he can prescribe another drug. Caution: Do not discontinue or change medication on your own!
Other causes
For an erection to come, not only the penis circulation must be right. All involved nerve tracts - from the penis to the spinal cord to the brain - must be intact. Herniated discs, injuries, radiation or pelvic or spinal cord surgery can cause erectile dysfunction. Also, diseases that can cause damage to peripheral nerves (a neuropathy) - such as diabetes mellitus (diabetes) or chronic alcohol abuse. Other possible causes of erectile dysfunction include diseases affecting the central nervous system, such as multiple sclerosis, Parkinson's disease, Alzheimer's disease or stroke. Serious diseases - such as cancer, severe kidney or liver disease - can always affect the potency with.
Psychic triggers
Physical and emotional triggers can be mixed in erectile dysfunction. If men suffer from physical problems with potency, they easily develop additional psychological problems. Purely psychologically caused causes can be found especially in younger men. In addition to conflicts in the partnership, stress, problems or anxiety disorders, depression is very often with associated with erectile dysfunction. In erectile dysfunction, the man can not get or maintain an erection sufficient for intercourse. The penis does not get hard enough and / or recovers quickly. The problems last for at least six months and occur in more than two-thirds of the cases. Often, erectile dysfunction (commonly called "impotence") gradually develops and occurs both in intercourse with the partner and in masturbation. This constellation indicates physical causes such as vascular changes (see chapter Causes). In every healthy man, erections occur in certain phases of sleep. If they stay out, this is another indication of physical causes. Does it only in very specific situations to erectile dysfunction and they are very sudden - almost from one day to the other - are the possible (but not proving) signs of psychic trigger.
With increasing age, the testosterone level in the blood drops slightly in almost all men. This is nothing unusual and no reason for a therapy. However, if a man suffers from erectile problems, a testosterone deficiency (hypogonadism) could play a decisive role. In this case, the doctor will advise to balance the hormone deficiency. Maybe this will already improve the potency problems. Often, erectile dysfunction medications (PDE-5 inhibitors, see below) are better or first in combination with hormone therapy. Some men with erectile dysfunction even benefit from testosterone supplements, although her blood levels are actually in a near normal range. When does the hormone supplement make sense? It should therefore be decided individually - jointly by doctor and patient. The testosterone is applied in the form of a gel on the skin or sprayed at greater intervals in the muscle. At first, research seemed to indicate that That a testosterone therapy could possibly increase the risk for prostate cancer or a heart attack. However, according to current knowledge such fears are unfounded, say experts - a professional medical treatment provided. Mostly, however, only the symptoms, not the actual triggers of erectile dysfunction can be treated. There are various options, from medication to mechanical aids. What helps best in an individual case is an individual decision the after extensive consultation on possible side effects and risks together with the doctor - and ideally, of course, together with the partner - should be taken. Patients themselves can help to maintain or even improve their potency for a long time. What keeps the blood vessels fit also prevents erectile dysfunction. In detail this means: Do not smoke, eat well, drink little alcohol, move a lot, lose weight, blood pressure, Check blood sugar and blood lipids regularly and treat them with bad results.
In Germany, various phosphodiesterase 5 inhibitors (PDE-5 inhibitors) are approved for the treatment of erectile dysfunction: the first was sildenafil, which was launched in 1998. Tadalafil, Vardenafil and Avanafil followed. All are prescription. Effect and side effects are roughly comparable. The tablets help about 70 to 80 percent of "impotent" men and differ mainly in dosage and duration of action. Sildenafil, vardenafil and avanafil work after about 15 to 60 minutes (the onset of effect may be delayed after high-fat meals). Their effect lasts around four to twelve hours. Tadalafil works after about 30 minutes for about 24 to 36 hours. This medication can also be prescribed as a permanent medication with one tablet a day. As the name suggests, the drugs inhibit phosphodiesterase-5 (PDE-5), which is an endogenous enzyme. This enzyme normally breaks down a certain messenger substance, which increases in sexual arousal and increases blood circulation in the penis. If the enzyme phosphodiesterase-5 is now obstructed in its work by the drugs, there is more messenger left. Consequently, penile blood flow increases, an erection develops or persists longer. A second effect is that the blood pressure in the pulmonary circulation drops. Phosphodiesterase 5 inhibitors are therefore also used to treat pulmonary hypertension. PDE-5 inhibitors only work if the man is sexually aroused. So you do not increase the desire. The erection ends - as without medication - with orgasm or ejaculation. Within the duration of action, however, further erections are possible. Possible side effects include headache, facial flushing, heartburn, stuffy nose, Transient changes in color vision in sildenafil and vardenafil, in Tadalafil also muscle and back pain. Exact information can be found in the leaflet. Not suitable are PDE-5 inhibitors for patients prescribed by the doctor nitrates or molsidomine, because it can lead to a dangerous drop in blood pressure here. Nitrates or molsidomine, for example, in the treatment of angina pectoris in coronary Heart disease used. Some diseases (for example, severe liver disease, Heart disease or a stroke in the past) may speak against taking PDE-5 inhibitors. The PDE-5 inhibitors are good for a prescription. Before the first application, patients should consult the doctor extensively on side effects and inform possible individual risks. Another drug for the treatment of erectile dysfunction is yohimbine, which acts in the brain and especially for psychically induced potency disorders is used.
Subcategories
Viagra or sildenafil will be used to treat adults to men with erectile dysfunction applied. That's the inability, one for a satisfying sexual intercourse to achieve sufficient erection or uphold. sildefanil can only work if a sexual stimulation is present How to use viagra? The recommended dose is 50mg, it is about 1 hour before sexual intercourse to take it. According to the
sity and compatibility The dose can be reduced increased to 100 mg or reduced to 25 mg
become. The recommended maximum dose is carries 100 mg. The intake must not be frequent.
than once a day. If VIAGRA taken with food is, the impact can be compared be delayed for fasting. Effects of sildenafil? Sildenafil provides an oral treatment of the erectile dysfunction. In a natural way, through sexual stimulation, the impaired erectile function due to an increase in the blood stream into the penis restored. The man responsible for the erection of the penis
The physiological mechanism closes the release of nitric oxide (NO)
in the corpus cavernosum during the se-
xual stimulation. The nitrogen mono-
oxide activates the enzyme guanylate cyclase,
waszuerhöhtenSpiegelnanzyklischem
Guanosine monophosphate (cGMP) leads. Here-
through it comes to a relaxation of
smooth muscles in the corpus cavernosum,
which allows the blood to flow.
Sildenafil is an effective and selective
Inhibitor of the cGMP-specific phosphorus
phodiesterase type 5 (PDE5) in the corpus
vernosum, where they work for the removal of cGMP
responsible for. silde
nafil has a peripheral effect
Erections. Sildenafil does not practice direct
relaxing effect on isolated human
Corpus cavernosum tissue, it
but enhances the relaxing effect
NO on this tissue. If under
sexual stimulation the activation of the
NO / cGMP metabolic pathway takes place,
causes PDE5 inhibition by sildenafil
increased cGMP levels in the corpus cavernos
sum. Therefore, a sexual stimulation
necessary for sildenafil to do the intended
can develop favorable pharmacological effect. Viagra causes a small and temporary
going reduction in blood pressure, which in
in most cases no clinically relevant
Apparitions result. On average,
contributed the maximum blood pressure decreases
lying down after taking 100 mg of Silica
denafil systolic 8.4 mmHg, diastolic
5.5 mmHg. This blood pressure reduction reflects
the vasodilator
reflected, possibly due to increased
cGMP level in the smooth muscle vascular
musculature. Single oral doses of up to 100 mg
Sildenafil showed in healthy volunteers
no clinically relevant ECG changes
gene.
In a study on the hemodynamic
Effects of a single oral dose of
Sildenafil 100 mg in 14 patients with
Severe (> 70% stenosis at least
coronary artery) coronary heart disease
(KHK) took the middle systolic
and the mean diastolic blood pressure in
Rest to the baseline around
7% and 6% respectively. The middle pulmonary
systolic blood pressure decreased by 9%.
Sildenafil did not affect the cardiac
it still affected the
Blood flow into the stenosed coronary
arteries.
In a double-blind placebo-controlled
The load study included 144 patients
with erectile dysfunction and stable chro
angina pectoris, the
antianginal medication (except
Nitrates). Under sildenafil occurred in the
Compared to placebo, no clinically relevant
differences in the time to
Occur an abortion-compelling angina.
Summary of the security profile
The safety profile of VIAGRA is based on
9,570 patients from 74 double-blind place-
bokontrollierten clinical trials. The most commonly described side effects
in patients treated with sildenafil
in clinical trials were headaches,
Flush, dyspepsia, stuffy nose, dizziness
del, nausea, hot flash, blurred vision,
Cyanopsia and blurred vision.
Avanafil is used to treat erectile dysfunction in adult men. Efficacy requires sexual arousal.
For the following application areas of Avanafil, in-depth information is available:
- erectile Dysfunction
Please also read the information on the drug classes Potency, Phosphodiesterase, to which the active ingredient avanafil belongs.
Areas of application according to the manufacturer's instructions
- Erectile dysfunction in adult men
The recommended dose is one 100 mg tablet taken by the man when needed approximately 30 minutes before sexual activity. Depending on individual efficacy and tolerability, the dose may be increased to a maximum of one 200 mg tablet or reduced to a 50 mg tablet.
The recommended maximum frequency of use is once a day. For a sufficient effect sexual arousal is required.
Frequent side effects of avanafil
Headache, feeling hot, nasal congestion.
Occasional side effects:
Dizziness, drowsiness, sinus pain, sinus congestion, blurred vision, palpitations, flushing, difficulty breathing, indigestion, nausea and vomiting, upset stomach, backache, muscle tension, fatigue, elevation of liver enzymes, abnormal ECG, accelerated heartbeat.
Rare side effects of spedra
Influenza, nasopharyngeal inflammation, seasons-related allergy, gout, insomnia, premature ejaculation, mood disorder, mental agitation, angina, palpitations, hypertension, nasal passages, upper respiratory obstruction, dry mouth, gastritis, abdominal pain, diarrhea, rash, flank pain, muscle aches , Muscle spasms, frequent urination, penile disorders, spontaneous erection, itching in the pubic area, weakness, chest pain, flu-like symptoms, water retention in the arms and legs, blood in the urine, heart murmurs, increased PSA, weight gain, increase in bilirubin levels in the blood , increased creatinine in the blood, increased body temperature.
Particularities:
Patients whose erection lasts four hours or more (priapism) should consult a doctor immediately. Left untreated, priapism damages the penis tissue, which can lead to permanent loss of potency.
Avanafil enhances the antihypertensive effects of nitro-based vasodilators. Therefore, the joint application is prohibited. If a patient who has taken avanafil within the last 12 hours or more has been given nitrates because of a life-threatening situation (such as a heart attack), the blood pressure may be lowered.
Avanafil has a vasodilating effect on the penis, but this effect can affect the whole body. Therefore, the drug increases the blood pressure reduction by appropriate drugs (alpha sympatholytic, calcium channel blocker). It can cause dizziness, drowsiness or fainting.
Avanafil is degraded by an easily influenced enzyme system. Therefore, the application is prohibited with strong inhibitors of these enzymes. These include: the fungicides itraconazole and ketoconazole, the antiviral agents atazanavir, indinavir, nelfinavir, ritonavir and saquinavir, the antibiotics clarithromycin and telithromycin and the antidepressant nefazodone.
Patients receiving at the same time weaker inhibitors of this enzyme (the antibiotic erythromycin, the antifungal agent fluconazole, the antiviral agents amprenavir and fosamprenavir, aprepitant (for nausea and vomiting), and the antidiabetic diltiazem or verapamil but also grapefruit juice) should not exceed the maximum dose of avanafil (100 Milligrams). Between the individual revenues should be a time interval of at least 48 hours.
Consuming alcohol while using spedra may increase the likelihood of a sudden drop in blood pressure. Therefore, you should abstain from drinking while taking.
Drugs that accelerate the degradation of avanafil may affect its performance. These include the antiepileptic drugs carbamazepine and phenobarbital, the tuberculosis drug rifampicin, the antiviral agent efavirenz and bosentan (for pulmonary hypertension). Although there are no studies, but should be avoided as a precaution, the joint application.
CIALIS is used to treat adult men with erectile dysfunction
applied. This is the case when a man does not have sexual activity
can get or maintain a hard, erect penis. CIALIS showed one
significant improvement, a hard, erect penis for sexual activity too
to get.
CIALIS contains tadalafil as an active ingredient and belongs to a group of medicines
called the "phosphodiesterase 5 inhibitors". After a sexual
Stimulating Tadalafil helps to relax the blood vessels in your penis
Blood flow into your penis is possible. The result is an improved erection.
CIALIS will not help you if you are not suffering from erectile dysfunction
Suffer.
It is important to note that CIALIS does not work without sexual stimulation. On
Partnership foreplay may be necessary, as if you were not a medicine
against erectile dysfunction.
CIALIS must not be taken if you:
- allergic to tadalafil or any of the other
Components of this medicine are.
- in any form organic nitrates or nitrogen oxide donors such as amyl nitrite
taking. This is a group of medicines ("nitrates") that are used for treatment
of angina pectoris (certain type of "heartache") are used. It
CIALIS has been shown to enhance the effects of these drugs. If you
take some form of nitrates, or are unsure, speak
with your doctor.
- suffer from a serious heart condition or one in the last 90 days
Had heart attack.
- had a stroke in the last 6 months.
- suffer from low or uncontrolled high blood pressure.
- ever a vision loss due to a non-arteritic anterior
Ischemic optic neuropathy (NAION), this disease is known as
"Stroke of the eye" described.
- Take riociguat. This medicine is used for treatment
of pulmonary arterial hypertension (i.e., high blood pressure in the lung) and
Chronic thromboembolic pulmonary hypertension (i.e., high blood pressure
in the lungs in addition to blood clots). PDE5 inhibitors, such as Cialis
have been shown to increase the antihypertensive effect of this drug.
If you are taking riociguat or are unsure, talk to your doctor
Always take this medicine exactly as your doctor has told you.
Ask your doctor or pharmacist if you are not sure.
CIALIS tablets are to be taken by men only. Swallow
the whole tablet with a little water. You can use CIALIS independently of the
Take meals.
The recommended starting dose
is a 10 mg tablet before sexual activity.
If the effect of this dosage is too low, your doctor may decide the dosage
increase to 20 mg.
You should take CIALIS at least 30 minutes before sexual activity.
CIALIS can work for up to 36 hours after taking the tablet.
Do not take CIALIS more than once a day. Tadalafil are 10 mg and 20 mg
Intended to be taken before expected sexual activity and daily
Intake for a long time is not recommended.
It is important to note that Tadalafil only works with sexual stimulation. On
Partnership foreplay may be necessary, as if you were not a medicine
against erectile dysfunction.
Alcohol consumption can affect your ability to get an erection and
can also temporarily lower your blood pressure. If you taken CIALIS
or if you plan to take CIALIS, avoid overeating
Drink (blood alcohol level of 0.8 ‰ and more), because this reduces the risk of
Dizziness when getting up can be increased.
If you take more Tadalafil than you
should
Tell your doctor. It could be that side effects occur, like in the
Section 4. described.
If you have any further questions on the use of this medicine, please contact
to your doctor or pharmacist.
Like all medicines, this medicine may also have side effects
but do not have to occur at everyone. These are usually mild to moderate.
Stop the treatment and notify a doctor immediately if
You notice any of the following side effects:
- allergic reactions, including rashes (uncommon).
- Chest pain - Do not use nitrates, take them immediately
medical assistance (frequency uncommon).
- Priapism, a prolonged and possibly painful erection can
occur after ingestion of CIALIS (frequency rare). Should you have an erection
If you have more than 4 hours, contact your doctor immediately
Doctor in contact.
- sudden loss of vision (frequency rare).
Other side effects have been reported:
Frequently
(may affect up to 1 in 10 people)
- Headache, backache, muscle aches, pain in the
Arms and legs, facial flushing, stuffy nose and indigestion.
Occasionally
(may affect up to 1 in 100 people)
- Dizziness, abdominal pain, nausea, vomiting, acid regurgitation (reflux
stomach acid), blurred vision, eye pain, difficulty
breathing, blood in urine, prolonged erection, palpitations, tachycardia (faster
Heartbeat), high blood pressure, low blood pressure, nosebleeds, ear noises
(Tinnitus), swelling of hands, feet or joints and fatigue.
Rare
(may affect up to 1 in 1000 people)
- Fainting, seizures and temporary memory loss,
Swelling of the eyelids, red eyes, sudden deafness or
Numbness, hives (itchy, red ridges of the skin), penile bleeding, blood
in the sperm and increased sweating.
Heart attacks and strokes have been rare in patients taking CIALIS
reported. Most of these men already had this before taking this
Arzeimittel known heart disease.
Partial, temporary or permanent deterioration or loss of
Eyesight of one or both eyes has been rarely reported.
Some more rare side effects
not seen in clinical trials
were reported in men who had taken CIALIS. These include:
- Migraines, facial swelling, severe allergic reactions,
which cause swelling in the face or neck, serious
Redness, some diseases that affect the blood flow to the eye,
irregular heartbeat, angina (heart attack) and sudden cardiac death.
Keep Tadalafil out of the sight and reach of children.
You must take this medicine after the carton and the blister pack
after 'verw. until 'or' EXP 'specified expiry date
• Dapoxetine is a drug in tablet form containing the active ingredient
Contains dapoxetine. It is used to treat premature
Ejaculation (Ejaculatio praecox) applied. Dapoxetine is
approved for men between 18 and 64 years.
• Dapoxetine (dapoxetine) is a serotonin reuptake inhibitor
(SSRI). Previous research has shown that serotonin
plays a central role for the ejaculation time.
• Dapoxetine blocks transport
substances that serotonin after
signal transmission back into the memory locations
return the parcel. Serotonin stays longer at the site of action, and
its effectiveness increases. SSRIs are mainly so far
for the treatment of depressive
Used diseases. in the
Unlike dapoxetine, one to three hours before sex
however, these antidepressants must be taken
be used regularly and over a longer period of time.
Important information
• Beware of orthostasis! Before the first input should
a doctor's inclination to one
orthostatic hypotension
exclude. Orthostatic Hypotension (OH) is a
morbid blood pressure drop at
m getting up from sitting or
lying position. The most
Healthy people can
happen that they briefly when raising quickly
Weakness, diffuse Sc
jib or one
Getting black before the eyes. One only speaks
from an OH if it constantly occurs and discomfort
caused.
• Avoid situations in which there is injury
can come, including driving a car or that
Operating dangerous machinery, syncopation or its should be
prodromal symptoms such as dizziness or drowsiness
occur. (*)
• It may be too after taking dapoxetine
Circulatory problems up to a circulatory collapse
come. * A sufficient Flü
fluid intake and the
Avoiding alcohol are wi
well, to prevent that!
Caution also at the same time
ger treatment with medication,
the one blood vessel
own effect, effect
and PDE5 inhibitors (potency agent, sildenafil), alpha
Adrenoceptor antagonists, nitrates.
• Do not take alcohol
within 24 hours before or after
taking Dapoxetine! The risk of side effects
Nervous system, heart and circulation can be increased.
• Dapoxetine must not be taken with drugs
become! Especially in combination with ketamine, LSD, MDMA,
Amphetamine, narcotics
and benzodiazepines
serious side effects occur.
• This medicine k
ann also under normal conditions
Use the ability to active
n participation in road traffic
or interfere with the operation of machinery. This is true in
increased degree in interaction with alcohol.
• Antidepressants increased the risk in short-term studies
suicidal thoughts in children
n and teenagers with strong
Depression. For Dapoxetine there was no reference to one
such increased risk.
• Dapoxetine was only given to men with premature ejaculation
tested. About effect and side effects in men without
Ejaculatio praecox no data available.
• Dapoxetine may cause blood clotting
influences. Be careful
simultaneous treatment with
Platelet aggregation inhibitors
(atypical antipsychotics, Phenot
hiazines, acetylsalicylic acid,
NSAIDs) or anticoagulants (Warfa
rin). People with bleeding
or coagulation disorders are particularly at risk.
• A sudden discontinuation v
on SSRI, which is longer
Period of administration may cause withdrawal symptoms
lead, for example, irritable bark
it, bad mood, dizziness,
Nervousness, insomnia and
A headache. When weaning
of Dapoxetine showed no or only slight in studies
Withdrawal symptoms.
• The initial dose is 1 tablet to 30 mg 1 to 3 hours before
sexual activity.
• Do not take DAPOXETINE more than once a day!
• Take with a glass of water with or without food.
• An increase to 60 mg is possible if the effect is not
sufficient and the side effects are tolerable. at
orthostatic reaction to di
Do not increase the 30 mg dose!
• The medicine is not for daily long-term therapy
suitable.
Listed are the most important known side effects. you
can occur, but not necessarily, because every human being
different responds to medication.
Sometimes people are allergic to medications. Should
You signs of an allergic
Feel reaction, inform
See your doctor or pharmacist immediately.
• Dizziness (very common)
• Headache (very common)
• Nausea (very common)
• Diarrhea, vomiting (common)
• Insomnia (common)
• Tiredness (common)
• Elevated blood pressure (often)
• Irritability, anxiety (common)
• Tinnitus (common)
• Blurred vision (often)
• Sweating (often)
• Erectile dysfunction (common)
Store drug out of reach of children.
You are allowed to use DAPOXETINE after the carton and the
Do not use the expiry date given on the blister pack.
Keep in original packaging to preview the contents
Moisture protection .. Do not store above 25 ° C.
The drug must not be in wastewater or household waste
be disposed of. Ask your pharmacist how the medicine works
is to be disposed of when you no longer need it.
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