What is avanafil or spedra?

Avanafil is used to treat erectile dysfunction in adult men. Efficacy requires sexual arousal.

For the following application areas of Avanafil, in-depth information is available:

- erectile Dysfunction

Please also read the information on the drug classes Potency, Phosphodiesterase, to which the active ingredient avanafil belongs.
Areas of application according to the manufacturer's instructions

- Erectile dysfunction in adult men

dosage of spedra

The recommended dose is one 100 mg tablet taken by the man when needed approximately 30 minutes before sexual activity. Depending on individual efficacy and tolerability, the dose may be increased to a maximum of one 200 mg tablet or reduced to a 50 mg tablet.

The recommended maximum frequency of use is once a day. For a sufficient effect sexual arousal is required.

side effects with spedra avanafil

Frequent side effects of avanafil
Headache, feeling hot, nasal congestion.

Occasional side effects:
Dizziness, drowsiness, sinus pain, sinus congestion, blurred vision, palpitations, flushing, difficulty breathing, indigestion, nausea and vomiting, upset stomach, backache, muscle tension, fatigue, elevation of liver enzymes, abnormal ECG, accelerated heartbeat.

Rare side effects of spedra
Influenza, nasopharyngeal inflammation, seasons-related allergy, gout, insomnia, premature ejaculation, mood disorder, mental agitation, angina, palpitations, hypertension, nasal passages, upper respiratory obstruction, dry mouth, gastritis, abdominal pain, diarrhea, rash, flank pain, muscle aches , Muscle spasms, frequent urination, penile disorders, spontaneous erection, itching in the pubic area, weakness, chest pain, flu-like symptoms, water retention in the arms and legs, blood in the urine, heart murmurs, increased PSA, weight gain, increase in bilirubin levels in the blood , increased creatinine in the blood, increased body temperature.

Particularities:
Patients whose erection lasts four hours or more (priapism) should consult a doctor immediately. Left untreated, priapism damages the penis tissue, which can lead to permanent loss of potency.

Interactions of avanafil

Avanafil enhances the antihypertensive effects of nitro-based vasodilators. Therefore, the joint application is prohibited. If a patient who has taken avanafil within the last 12 hours or more has been given nitrates because of a life-threatening situation (such as a heart attack), the blood pressure may be lowered.

Avanafil has a vasodilating effect on the penis, but this effect can affect the whole body. Therefore, the drug increases the blood pressure reduction by appropriate drugs (alpha sympatholytic, calcium channel blocker). It can cause dizziness, drowsiness or fainting.

Avanafil is degraded by an easily influenced enzyme system. Therefore, the application is prohibited with strong inhibitors of these enzymes. These include: the fungicides itraconazole and ketoconazole, the antiviral agents atazanavir, indinavir, nelfinavir, ritonavir and saquinavir, the antibiotics clarithromycin and telithromycin and the antidepressant nefazodone.

Patients receiving at the same time weaker inhibitors of this enzyme (the antibiotic erythromycin, the antifungal agent fluconazole, the antiviral agents amprenavir and fosamprenavir, aprepitant (for nausea and vomiting), and the antidiabetic diltiazem or verapamil but also grapefruit juice) should not exceed the maximum dose of avanafil (100 Milligrams). Between the individual revenues should be a time interval of at least 48 hours.

Consuming alcohol while using spedra may increase the likelihood of a sudden drop in blood pressure. Therefore, you should abstain from drinking while taking.

Drugs that accelerate the degradation of avanafil may affect its performance. These include the antiepileptic drugs carbamazepine and phenobarbital, the tuberculosis drug rifampicin, the antiviral agent efavirenz and bosentan (for pulmonary hypertension). Although there are no studies, but should be avoided as a precaution, the joint application.