What is Triptorelin (GnRH)?

Synthetic analogue GnRH.

Testimony of Triptorelin

Diseases that require a reduced level of sex hormones (including symptomatic treatment of carcinoma of the prostate gland). Endometriosis, uterine fibroids, vitro fertilization.

To reduce the size of uterine fibroids in cases of imminent surgical removal of fibroids or hysterectomy; Endometriosis, confirmed laparoscopically, if there is evidence to suppress the function of the ovaries and no need for surgical intervention.

Dosage of Triptorelin

Individual, depending on the indications, the dosage form and treatment regimen.

Side effects of Triptorelin

On the part of the genital system: vaginal dryness, pain during sexual intercourse, weight gain, decreased libido (in women and men), the appearance of spotting vaginal discharge, gynecomastia (in men), impotence.

From the CNS and peripheral nervous system: rarely headache, sleep disturbances, depression, fatigue, paresthesia, visual impairment, back pain, irritability.

On the part of the digestive system: nausea, increased cholesterol in plasma, increased levels of hepatic enzymes.

Other: Tides with perspiration, reduction of bone density; Rarely allergic reactions.

Contraindications of Triptorelin (GnRH)

Ovarian polycystic syndrome, pregnancy, lactation, hypersensitivity to Triptorelin.

Pregnancy and lactation

contraindicated in pregnancy, during lactation.

Special Instructions for using Triptorelin

Side effects are reversible. Before the beginning of therapy should completely exclude the presence of pregnancy. Menstruation usually occurs 3 months after the last injection of the depot-form, but in some cases later.

In the process of therapy should regularly monitor the level of sexual steroid hormones in plasma (in men and women), as well as the size of fibroids (including by ultrasound). It should be borne in mind that a disproportionately rapid decrease in uterine volume, in comparison with the size of fibroids, may in some cases cause bleeding and sepsis.

To prevent hyperstimulation, it is necessary to carefully control the growth of the follicles and the lutein phase, especially when ovaries. During the first month of therapy, women should use non-hormonal contraceptives.

In men at the beginning of treatment may increase the level of testosterone in plasma, so during the first week of therapy is recommended careful monitoring of the patient's condition and, if necessary, symptomatic therapy.